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Thursday, April 23rd, 2026 07:53 pm

New behaviour from Gideon.

Every so often he'll see a small trinket he can spend some pocket money on. A waddle-dee or a Yoshi toy.

And he'll buy one, take it home, and carefully place it on Jane's bedside table, for her to enjoy.

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Thursday, April 23rd, 2026 08:36 pm
The GL Thai drama ClaireBell was excellent. Bell gets wrongly arrested. In prison, she meets Claire, who helps her survive.

If you love shows full of interesting female characters like Orange is the New Black, go for it. There's major f/f.

It's available legally and for free on YouTube.
Thursday, April 23rd, 2026 02:18 pm

You can put this one in the “reactions I never expected to see” category, because it’s a way to selectively functionalize aryl rings with multiple fluorines on them. And no, I don’t mean “functionalize at the carbon(s) that aren’t fluorinated yet” or even “kick out the most likely SnAr leaving group fluorine”. This is stepping and and replacing fluorines with H, D, alkyls or other aryls.

The reason this looks so odd is that most of the time in organic chemistry breaking a C-F bond is going to be an uphill climb. They’re pretty strong as a rule, which is one reason why we medicinal chemists use them as blocking groups on carbons that are likely to undergo oxidative metabolism when a drug candidate hits the CYP enzymes in the liver. Fluorine has a number of other effects that can be attributed to its powerful electronegativity, and fluorination is very likely to change not only the metabolic profile of your compound, but to affect binding to proteins and to change solubility and other physical properties as well. 

So there are a number of ways to add fluorines to various parts of a molecule, under reaction conditions that range from not-so-bad to dive-behind-a-wall, but taking them back off? Not so many. The one that springs to mind is that I mentioned above, nucleophilic aromatic substitution. You can displace an aryl fluoride if the ring it’s on is suitably activated, and it’s a really useful reaction. para-Fuoro nitrobenzene or para-fluorobenzaldehyde are textbook examples: this reaction goes through an anionic intermediate that then kicks the fluorine back out to restore the aromatic ring, and groups that make that anionic state less painful accelerate things. But if you want to try it on a neutral or electron-rich aryl instead, then good luck to you. 

The new paper linked above is a different thing entirely, and I don’t think I’ve ever seen anything quite like it. The fluorinated starting material reaction with a pyridine-borane reagent that attacks at a particular C-F bond to generate a radical intermediate, and this is what loses the (solvated) fluoride to generate a borylaryl radical cation with a fluoride as the ion pair. That’s the species that then gets attacked by the coupling partner, forming a new C-C (or CH or CD) bond and kicking out a B-F side product. 

If you change the nature of the borane-pyridine reagent (by substitutions on the pyridine) you can tune this to take out different fluorines in order, and the authors demonstrate some of these stepwise functionalizations, all the way out to four steps. A variety of groups can be coupled under these conditions (substituted aryls, heteroaryls, substituted alkyls including alpha-amino couplings, alkenes (to give alkyl chains), and more. It’s quite weird to see, and will give retrosynthesis planners an entirely new way to thing about potential routes. And you can of course combine this new chemistry with a step of good ol’ SnAr from a suitable starting material for even more variety. It’s going to take me a bit to start envisioning polyfluoroaryls as versatile starting materials, though!

Thursday, April 23rd, 2026 05:59 pm

Posted by Ask a Manager

A reader writes:

I have recently made it to the second round of interviews for a role I’m very interested in. The conversation is with the person who is leaving the role I’m interviewing for.

I’ve never interviewed with the person who is currently in the job in question, but I take that to mean that she’s leaving the organization on good terms and for her own reasons, and that they trust her to make a recommendation on who will succeed her. Would you agree with that take on the situation, and if so what kinds of questions do you think I should ask or expect? How do I sell myself for the role without coming across as “I’m going to be better at this than you were,” which I’m sure would be a turn-off?

There are two possibilities:

1. The interview is primarily for her to evaluate you as a candidate and, while you’ll still have the opportunity to ask your own questions, it’ll be more or less like any other interview and you should approach it that way.

2.. Or, the main purpose of this meeting is for you to be able to talk to the person who’s currently doing the job and get your own questions about the role answered. In this scenario, she will likely still provide feedback to the hiring manager about you and other candidates, but it’s not the primary purpose of the conversation.

Have they said anything to indicate which it is? Sometimes an employer will say something like, “We’d like to give you some time to talk with the person who’s doing the job now so she can tell you about the work with more nuance” — and that’s a sign that it’s more likely to be #2 (or at least mostly #2). Or they might not say anything like that in advance, but when you sit down with her she’ll make it clear that that’s the bulk of the agenda.

Either way, you should prepare for both scenarios — meaning that you should come into it expecting #1, but be ready with a lot of your own questions if it tuns out to be #2. (You should be ready with a lot of your own questions regardless — because in either scenario it’s an opportunity to hear firsthand from the person who’s doing the job now — but if it turns out to be #2, you don’t want the conversation to stall because you only prepared a couple of questions.)

Questions you can ask the person who’s doing the job you’re interviewing for include things like the best things about the job, the most challenging things about the job, the manager’s management style, secrets to success for doing well in the role, and whether there’s anything she was surprised by or wished she’d known before she started. You should also ask about workload, what the busiest times of the year are, and what those look like, because you might get a more accurate/honest answer than you will from others. And depending on the job, you might ask technical questions too, like what software they’re using for X, or how they’re handling a particular known challenge with that software, etc.

As for selling yourself without coming across like you think you’ll be better at the job than she was … I’d argue you should never really be coming across that way in an interview, even when you’re not talking to the person you’d be replacing, since you can’t possibly know from the outside if it’s true! Good interviews don’t feel like sales pitches; the best ones feel like a conversation between two potential colleagues trying to figure out if a collaboration between them would make sense — and that’s how you should approach this too. Listen to what they’re looking for, talk about how you might be able to help with that, pull out things from your professional history that relate to what they need, and — while they’re assessing you — ask the questions that will help you assess them back.

The post how do I interview with the person I would be replacing? appeared first on Ask a Manager.

Thursday, April 23rd, 2026 05:28 pm

Posted by Heather Rose Jones

Thursday, April 23, 2026 - 10:15

You know that guy in your field who everyone cites but every time you read one of their articles you constantly mutter, "But you're ignoring X and you're redefining Y  solely in order to support your pet theory, and you're simply wrong about Z"? Yeah, one of those guys. There are several on my list and Hitchcock is one of them.

Major category: 
Full citation: 

Hitchcock, Tim. 1996. “Redefining Sex in Eighteenth-Century England” in History Workshop Journal, No. 41: 72-90

As much of this material is functionally identical to what’s discussed in Hitchcock 2012, I’m going to skim more than usual.

The article opens with a quote from an early 18th century memoir discussing in candid detail the erotic practices of two unmarried people. The couple had an extended relationship that never resulted in marriage and yet considered that they “never acted [in a way] which might bring us disgrace” or in a way that compromised the woman’s virginity. To the extent that “sex” outside of marriage was forbidden, the details point out the range of erotic activities that were not considered “sex” at that time, including “amorous talks and quaint glances, kissing and toying when together in private…[she] came to [his] bedside…tender and loving kisses.”

Hitchcock compares this extensive inventory of acceptable non-procreative activities to the demonstrable demographics of the late 18th century which reflect a much higher incidence of procreative sex, both before and after marriage. This same shift in emphasis is seen during the same period in pornography and novels. Hitchcock asserts that this would seem to be in conflict with other historical trends: the rise of the “separate spheres” view of gender, the increasing emphasis on motherhood as women’s primary identity, and the rise of homosocial segregation at home and the workplace.

[Note: As I commented for Hitchcock 2012, this supposed conflict disappears if one views the shift in sexual attitudes as being driven by a prioritization of men’s desires, rather than a general shift in attitudes across the genders. As women are the people who get pregnant, they are the primary beneficiaries of non-procreative sex.]

The article reviews various demographic trends that appeared across the 18th century: lower age at first marriage, increasing percentages of children born out of marriage or marriages where the bride was already pregnant, decreasing percentages of never-married people.

Historians have proposed various explanations for these shifts including economic dynamics (which don’t’ always align well on a cause-effect basis), a shift to the idea of a “companionate” marriage prioritizing familial affection and less parental control over partner choice, or even the influence of attitudes towards “productivity” that saw children as a desirable economic product. These explanations remain largely speculative.

From another angle, literary movements (pornography, the rise of the novel, enlightenment philosophy) reflect a growing libertinism, but one which emphasized male sexual pleasure, revolving around the penis, with a greater openness in discussing sexual matters. Hitchcock suggests this is at odds with trends in women’s history, with women finding their access to public participation increasingly limited (both socially and professionally) at the same time there was increasing patriarchal control within the household. [Note: once again, I don’t see a conflict if one views the “increasing openness and focus on pleasure” as benefitting men alone. ‘More sex” might be liberating for men but could be a form of repression for women.]

Hitchcock asserts that this move toward more sex “we must assume was largely consensual” but I think that needs to be examined more closely. He notes that another parallel change around the 18th century in theories of sexuality was a rejection of the medical theory that female orgasm was essential to conception. This change undermined the importance of women’s sexual experiences within marriage. If their orgasms were irrelevant to procreation, then their sexual desires could not only be ignored (by men) but could be denied entirely (the shift to the “passionless woman” model of sexuality). Whatever the direction of causality [note: Hitchcock omits mention of other political shifts around the late 18th century that contributed to anxiety and distrust of women’s sexuality] these trends align.

Hitchcock suggests that viewing these trends in terms of “men’s liberation/women’s repression” reflects an ahistorical adoption of “the extreme polarities of modern gender politics” and suggests instead that they resulted from a revolution in the definition of “what constitutes sex.” The demographic shifts reflect specifically the prevalence of PIV procreative sex, but say little about other types of activities. We do have evidence of changes in social attitudes [note: at least from the authoritative establishment] such as the fashion for anti-masturbation literature and associated attitudes by medical authorities. He makes an unsupported claim that “the demands of narrative structure” of pornography supports a focus on penetrative sex as “while erotica may be about fondling pornography is generally about penetration.” [Note: Anyone who had engaged in the definitional wars around the boundaries of erotica and pornography will see the flaws in this statement.]

Left unexamined is the directionality of causation. Hitchcock asserts “If women were seen to be increasingly passive, then the necessity of sexually satisfying anyone other than the male participant was obviated, and penetration became the quickest way of doing this.” But the same scenario could be framed as “If authors focused entirely on the sexual satisfaction of the male participant, in the form of penetration, then the sexual desires and experiences of women were necessarily backgrounded, and to avoid framing the man as actively indifferent to female pleasure, the existence of female pleasure must be denied.”

Hitchcock gives a slight nod to this directional ambiguity in saying that the shift in sexual framing “reflected and contributed to” the general repression of women’s role in society. Implicit in the rise of focus on penetrative sex was the assignment of responsibility for control of procreation to women—a responsibility they had increasingly less power to wield.

In addition to the fashion for anti-masturbation literature, there was a rise in “sex manuals” that focused entirely on techniques that increased the likelihood of pregnancy (and, unscientifically, on the likelihood of male offspring). So, to the extent that people were shaping their behavior to the dictates of conduct literature (and we should assume that large swathes of the population didn’t have access to it), positive discussions of sex were entirely about procreation and non-procreative sex appeared only as the target of suppression. With female orgasm eliminated as a component of procreation, techniques focused on women’s pleasure were not part of the program of sex manuals.

The article concludes with a discussion of how homosexuality fits into all this, but Hitchcock relies strongly on the timelines promoted by Randolph Trumbach, which have significant flaws with regard to the history of lesbianism. In particular, there is an assertion that prior to the 18th century, female homoeroticism existed primarily in the context of cross-dressing (an assertion that is easily contradicted), and that the disappearance of female cross-dressing narratives from popular culture by the end of the 18th century marks a significant shift in behavior (as opposed to a shift in the topics highlighted in popular culture—as there is plentiful evidence for passing/cross-dressing women in the 19th century, as well as new forms of female masculinity). Further, Hitchcock asserts that “the rise of romantic friendship from mid-century” is part of this larger overall shifts, while ignoring the forms romantic friendship took as early as the 17th century.

All in all, it’s unsurprising that my opinions on Hitchcock’s later article also apply to this earlier work.

Time period: 
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Thursday, April 23rd, 2026 04:29 pm

Posted by Ask a Manager

Here’s some coverage of Ask a Manager in the media recently:

I talked to Time about communication habits that are annoying your coworkers.

I talked to Bloomberg about how managers should discuss pay with employees.

I helped MarketWatch advise a letter-writer whose employee told her boss the writer was judgmental and belittling for giving feedback.

Huffington Post quoted me about what to say if a coworker is staring at your chest.

Also…

How to report problem ads

We’ve had a rash of ads auto-playing sound recently and are trying to get them all blocked, but if you encounter one (or any kind of problematic ad), the best way to report it is: look for the PubNation logo (“PN”) beneath the ad, click it, and a window will open with a report form to fill out, which will make it much, much easier for us to locate the and block it. Thank you!

The post Ask a Manager in the media … and how to report problem ads appeared first on Ask a Manager.

Thursday, April 23rd, 2026 04:59 pm

Posted by Shepherd

On April 2 of this year, the Radio-Canada (Canada's French national broadcaster; not actually just radio) program Enquête uncovered a Quebec maple syrup producer selling adulterated syrup, labeled as pure, that was actually 50% corn syrup, under his business -- the numbered corporation 9227-8712 Québec inc. aka "Érablière Steve Bourdeau". But there's more.

On April 9, Bourdeau's fake maple syrup -- which Bourdeau claimed he had pulled — was found still being sold in stores, now with the original name stickered over as "le sirop Angela." Officials said on April 10 that Boudreau had been under investigation for months, and that to their knowledge, this is the first instance of bogus maple syrup in Quebec. Things became even sticker on April 14, when more re-stickered product turned up on store shelves, this time as "L'Érabeille". On April 16, inspectors found staff at Bourdeau's facility pouring the canned syrup back into large containers, with Bourdeau saying "I'll find a way to get rid of it." In the interim, a class action lawsuit has been filed against Bourdeau for betraying consumer trust. And on April 22, the Quebec Federation of Maple Syrup Producers, known by its French acronym PPAQ, has called Bourdeau a "notorious and repeat offender," and has filed to launch a full investigation into Bourdeau's business, shut down his operations, and seize all his syrup. Bourdeau has claimed "suppliers" are responsible for the issues. Insurance Business Magazine speculates that this case may have larger effects on food and recall insurance in the long run. While this is the first known instance of widespread syrup fraud in Quebec, syrup theft is not unknown, including the Great Canadian Maple Syrup Heist, the theft of the International Strategic Reserve of syrup in 2011 and 2012. The largest heist in Canadian history, it was later adapted as TV show "The Sticky" in 2024.
Thursday, April 23rd, 2026 05:55 pm

Involved in proving, for certain life admin purposes, that partner and I are real people who are who we say we are, involving downloading an app, which one then has to validate by entering one's ID and they will send a code by text 'may take a few minutes', they have a very capacious definition of 'few minutes', ahem. Then entering various details, scanning various documents to a satisfactory quality (don't ask, just don't ask, I have done screaming now, thanks), and taking a selfie.

***

Do we even wish to detain ourselves over Michael Billington's ranking of the works of the Bard? I pretty much Dorothy Parkered, as much as one can with a newspaper, when I saw he had not only put Much Ado 20th out of 35, but considers B&B the subplot.

Light the barbecue in the marketplace, I have a heart to eat there!

***

Though it is hardly anywhere near the same class for utter crassness of this - honestly, why are these people? A tourist has been charged after allegedly climbing a colossal marble statue in Florence to touch its genitals for a pre-wedding prank.

Thursday, April 23rd, 2026 05:11 pm
So mostly these days I am obsessed with The Pitt! I love the show so much, for itself, and because it's such a natural successor to MASH and other shows I have loved. I've said on Bluesky that it's the only show I've ever come across that really understands how teaching and growth and mentoring happen in a professional environment - fandom is full of academia stories, and indeed academics, and school and high school stories, but not so much the grown-up, affirming, important work of teaching someone to do your job because you, they and the job all matter. (What do I teach people to do! Not save lives. But it matters. I had a lovely, lovely email from one of my team before she went off on maternity leave that said wonderful things about my teaching, about what she'd learned from me, how her practice had changed as a result of me, at which point I had to go and lie down and cry for a while. When Robby says with emphasis, "This is a teaching hospital", it makes me think of it.

(Brief outline: Robby, otherwise Dr Michael Robinavitch, is a warm, scathing, compassionate soul who runs an emergency department in Pittsburgh, it's an ensemble cast of interns, resident doctors, patients, nurses and others and Robby is the keystone of it all in a tired, mentally ill kind of a way. Each episode of the show covers an hour, so the entire season covers a single shift. It's very good. Also Robby is played by Noah Wyle - and, as the show's executive producers lost a litigation against the IP-holders for ER, he is emphatically not John Carter. I love this. Robby feels, and is, beautifully imagined: a working-class Jewish man, who wears a magen David necklace, all because Carter was a WASP with a trust fund.)

I also love Trinity Santos, a brilliant lovely Filipina asshole of a lesbian, and Jack Abbot, who is Robby's friend and also mirror image - being to the night shift what Robby is the day - and also fascinating for himself. He's a former MASH combat medic which is what decided me for sure that the show deliberately draws on its predecessor. The Pitt isn't a sitcom, but it has the warmth MASH had; and Abbot, who is a lower-leg amputee, embodies some of its ambivalence. (And! In s2 they have someone deliver Henry Blake's "young men die" speech, with the same blocking as the original. I love it.)

Anyway I love this show. It is so rich and funny and so fucking human, all the damn time. Robby's PTSD is from covid, and his nightmares are of full PPE - and I was like, okay, do I want to watch this. Robby has PTSD from treating covid patients but my dad died from treating covid patients. But I did want to watch it, because it takes what it does seriously. I want to write a fic, about Robby and s2 spoiler ), and I also want it to be a daemon AU, because I am insane. I haven't written anything good in a year and like I said I am insane. Maybe I should just ask people to give me fic prompts.
Thursday, April 23rd, 2026 03:36 pm

Posted by Christ, what an asshole

Sleepyhead is... Weird. YouTuber/musician Ego Dip deconstructs/reconstructs Passion Pit's most interesting track from scratch.